Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, Hemiscorpius lepturus

Hemicalcin , a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine - sensitive Ca 2 + channels by

Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels.

In the present work, we purified and characterized a novel toxin named hemicalcin from the venom of the Iranian chactoid scorpion Hemiscorpius lepturus where it represents 0.6% of the total protein content. It is a 33-mer basic peptide reticulated by three disulfide bridges, and that shares between 85 and 91% sequence identity with four other toxins, all known or supposed to be active on ryanod...

Toxic Effects of Scorpion, Hemiscorpius Lepturus (hemiscorpiidae) Venom on Mice

Scorpion stings are common in Iran, particularly in the southern and southwest regions of the country, and they pose a serious health problem. Hemiscorpius lepturus is the most venomous scorpion in the region. The present study was conducted to investigate the in vivo effects of scorpion venom in experimental mice. Haematological parameters (white and red blood cells numbers and haematocrit lev...

Purification and characterization of a novel type of neurotoxic peptides from the venom of the Iranian scorpion Hemiscorpius lepturus

Objective(s): Scorpion venom has toxic effects on mammals, insects and crustaceans.  Toxicogenic peptides are major contributors to the scorpion venom, which make it toxic. The Hemiscorpius lepturus (H. lepturus) is one of the most common scorpion bites agent, and responsible for 95% of scorpion bite deaths cases in Iran.Materials and Methods:</strong...

Venom Components of Iranian Scorpion Hemiscorpius lepturus Inhibit the Growth and Replication of Human Immunodeficiency Virus 1 (HIV-1)

BACKGROUND During the recent years, significant progress has been achieved on development of novel anti-viral drugs. Natural products are assumed as the potential sources of novel anti-viral drugs; therefore, there are some previous studies reporting the anti-viral compounds from venomous animals. Based on the significant value for tracing of non-toxic anti-viral agents from natural resources, ...